Limitations of Current Causality Assessment Methods
Confounding Variables
Current methodologies exhibit inadequate mechanisms for controlling
confounding factors, notably polypharmacy and comorbid conditions.
Experiential Bias in Assessment
The accuracy and reliability exhibit a significant dependence on the
assessor's level of experience and expertise, potentially
limiting accessibility and reproducibility of the assessment
process.
Scoring Variability
Inter-rater Variability Subjective interpretation of assessment
criteria leads to inconsistent scoring across different assessors,
potentially compromising the reproducibility of results.
Limited Applicability
Existing conventional methodologies, primarily developed within the
framework of clinical trials, demonstrate limited efficacy in
evaluating idiosyncratic hepatotoxicity associated with traditional
medicine use.